Advice on Prescribing Miconazole for patients taking Warfarin

Coumarins and related drugs + Azoles; Miconazole

The anticoagulant effects of acenocoumarol, phenprocoumon, and warfarin can be greatly increased if miconazole is given orally as an oral (buccal) gel, and bleeding can occur. Oral miconazole has also been reported to interact with ethyl biscoumacetate, fluindione, phenindione and tioclomarol in a few reports. The interaction has also rarely been seen in some women using intravaginal miconazole, and in those using a miconazole cream on the skin.

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